Bandits broke into the Castries Comprehensive Secondary (CCSS) for the fifth time in the past few months, sometime between Friday night and early Saturday morning.
They took with them several electronic items, cash and other valuables, but not before breaking several doors and ransacking the entire school.
This latest break-in comes days after several businesses and schools were looted during the passage of Tropical Storm Matthew, which has been strongly condemned.
Prime Minister Allen Chastanet visited the CCSS on Saturday and discussed plans to better secure the school and has promised the principal and staff, to replace the stolen items.
The school has been a frequent target for bandits.
The National Skills Development Centre located at Bisee and the Carmen Rene Primary School located at Sans Soucis, Castries also suffered recent breaks-ins.
Persons with information about these incidents are asked to contact the police.